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GSH is synthesized from glycine, L-cysteine and L-glutamate, and the system XC− cystine/glutamate antiporter, which comprises a light-chain subunit (SLC7A11, xCT) and a heavy-chain subunit (SLC3A2, CD98hc), mainly regulates the exchange of intracellular L-glutamate and extracellular L-cystine

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