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Blocking NNMT is therefore proposed to raise intracellular SAM, shift nicotinamide back toward NAD+ production, and alter the epigenetic landscape of adipocytes in ways that reduce lipid storage

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Substitution of the target concentration (TC) for concentration (C) in equation (4) predicts the maintenance dosing rate: Thus, if the desired target concentration is known, the clearance in that patient will determine the dosing rate