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It occurs when, during a period of hypoxia, commonly caused by ischemia, mitochondria become over-reduced, such that when O 2 is readmitted (‘perfusion’), it is reduced not with four electrons as normal (to water) by cytochrome oxidase but to peroxide and superoxide by complexes III and I, respectively (Figure 8)

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therefore, 99.8% of OTA is in albumin-bound form in the human circulatory system [28]