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A 2026 critical review of intravenous longevity therapy in Acta Dermatovenerologica Alpina, Pannonica et Adriatica makes the counterpoint clinics should not skip: the rationale for IV delivery is that it bypasses gut absorption limits and reaches supraphysiological plasma concentrations, but the reported benefits come largely from small clinical series and disease-specific or aesthetic contexts rather than trials in healthy adults (PMID 41915584)