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[33-35] The NNT of pregabalin is 4.9 while its NNHs are 4.3 and 6.3 for minor and major harms respectively
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This phenomenon is further complicated by reported no observed adverse effect levels (NOAELs) that vary by 2β3 orders of magnitude across studies, likely reflecting differences in metabolic processing, genetic susceptibility, and methodological approaches ( 1.3 Objectives of this review This comprehensive review synthesizes current evidence (2019β2024) regarding EED-mediated reproductive toxicity in males, with particular emphasis on: Mechanistic Understanding: Elucidating the molecular pathways through which EEDs disrupt male reproductive function, including oxidative stress cascades, endocrine signaling interference, and epigenetic modifications