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The findings indicated that ADSC-Exo could regulate the Atf3/Slc7a11 axis, reduce lipid peroxidation and iron accumulation, inhibit inflammatory microenvironments, and promote neuronal survival, significantly improving neurofunction in I/R-injured mice (Wang et al., 2024)
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Also, since some anti-angiogenic therapeutics, like TK inhibitors, show extensive toxicity when used in combination with chemotherapy [135], studying the interaction between the VEGF pathway and stemness/EMT might help identify anti-VEGF therapies that can also attenuate stemness/EMT and thus obviate the need for combinatorial treatments