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No significant statistical differences were observed in the basal levels of serum folate, HCY, and B12 among individuals with VCD, those who had recovered from the impairment, and non-impaired individuals, as detailed in Additional file 3

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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset — they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects