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Importantly, these metabolic changes were not reversed by LOS, possibly because competitive antagonism may not fully block AGTR1 under supraphysiological AngII concentrations, leaving residual receptor activity that could sustain bioenergetic adjustments through mechanisms, such as Ca 2+ -linked events, that are probably pharmacologically less sensitive and functionally buffered by the high basal metabolic tone of T24 cells

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Serial PiB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease