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Some studies have documented the association between apoE isoforms and diseases such as Alzheimer's disease, atherosclerosis, liver disease caused by HCV, human immunodeficiency virus (HIV) infection, HIV-associated dementia, pulmonary tuberculosis, childhood diarrhoea and herpes simplex virus infection [5,7,11,12]

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They can damage cell membranes, proteins, and even DNA if they are not neutralized quickly