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To investigate the potential off-target effect of ACA, stably SLC13A3 -knockdown HepG2 and SNU398 cells were transfected with respective overexpressing plasmids ( EV, PLA2, AP2M1, TRPM2, SLC13A3, or SLC13A5 ) for 6 h, followed by ACA treatment at different concentration

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In addition, the AIM-HIGH trial demonstrated that the concurrent use of extended-release niacin (1500-2000 mg/day PO) and simvastatin does not result in a greater reduction in the incidence of cardiovascular events than simvastatin alone