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The use of assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) can bypass some of the natural selection mechanisms that would prevent sperm with damaged DNA from fertilizing an egg, potentially leading to long-term consequences for the offspring

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Criteria for necrosis included karyorrhexis (loss of nucleus) and/or degeneration of cytoplasm with either coagulative or liquefactive changes