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MALDI-QIT-TOF-MS analysis showed that in unstimulated RAW264.7 cells, there were four phosphorylated residues including Tyr3, Tyr7, Ser42, and Tyr198 in GSTP, whereas five phosphorylated amino acids including Tyr3, Tyr7, Ser42, Tyr198, and Ser184 in GSTP could be observed in LPS-stimulated cells (Figure 5A)

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If you're a 55-year-old experiencing subjective cognitive decline and you're evaluating NAD+ therapy, the honest clinical assessment is: there's a plausible mechanistic basis for benefit, early clinical signals in specific populations, and reasonable safety data, but no definitive proof that it will reverse or prevent cognitive aging in your individual case