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Carnitine-Acylcarnitine Translocase Deficiency - an overview | ScienceDirect Topics

Researchers theorize that asthma may be due to either inappropriate mast cell activation or that the mast cells are hypersecretory.[ref][ref] One study sums up that mast cells release “preformed mediators including chymase, tryptase, and histamine and de novo synthesized mediators such as PGD2, LTC4, and LTE4 in addition of cytokines mainly TGFβ1, TSLP, IL-33, IL-4, and IL-13 participate in the pathogenesis of asthma.”[ref] Related article : Asthma: understanding the genetics and underlying causes Osteoarthritis: Mast cells as a causative factor Osteoarthritis, the most common form of arthritis, is caused by inflammation and degeneration of the joint tissue

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Moreover, dehydroabietic acid increases the expression of key ferroptosis genes such as FSP1