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The histopathological assessment and scoring approach were performed in accordance with validated methods previously described in similar ischemia-reperfusion studies 10,14

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As shown in Figure 6, NaT treatment caused downregulation of SIRT1/PGC1 α , Nrf2, and Parkin protein expression, and upregulation of p-P38/P38, LC3II/LC3I, and P62 protein expression in pancreatic tissue, while VB 12 reversed these changes (protein quantification results in Fig