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These PUFAs are incorporated into phospholipids, making cellular membranes more prone to ferroptosis due to their high susceptibility to lipid peroxidation ( 3.2 Lipid uptake Cells can absorb free fatty acids or lipoproteins from the extracellular environment through transporters such as CD36, fatty acid transport proteins (FATPs), and fatty acid-binding proteins (FABPs) ( + T cells, blocking CD36 and restoring their antitumor activity ( 3.3 β-Oxidation β -Oxidation is a process that breaks down fatty acids into acetyl-CoA units, primarily occurring in the mitochondria