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He explains how playful activities trigger the release of specific brain chemicals that create ideal conditions for learning and adaptability, and describes how the brain's play circuits remain active throughout adulthood, influencing behavior and social interactions

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In canonical Wnt/β-catenin signaling, the secreted Wnt proteins bind with the Frizzled receptor and a co-receptor of the low-density lipoprotein-related protein (LRP), thereby inactivating glycogen synthase kinase-3β (GSK-3β), which is an enzyme responsible for phosphorylation and ubiquitination-mediated degradation of β-catenin