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Nivolumab, pembrolizumab, and avelumab bind to programmed cell death ligand-1 (PD-L1), enhancing the host immune response by preventing tumor cells from suppressing endogenous T-cell activity

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It has previously been suggested that mucosal immunity tends to be short-lived and that vaccines targeted to the mucosa may be less immunogenic at these sites [43], which are limitations that need to be overcome for efficacious mucosal-targeted vaccines