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Semaglutide studies show weight regain after discontinuation, suggesting the need for long-term use or lifestyle maintenance strategies

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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic low‑grade inflammation with abundant release of pro‑inflammatory factors (such as TNF‑α and IL‑6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

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