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Although HF development occurs predominantly during the embryonic life, over- and/or under-activation of signaling pathways, such as sonic hedgehog (shh), notch, TGF-β, and Wnt/β-catenin, which regulate epithelial–mesenchymal interaction in HF, play roles in periodic regeneration of HF and, hence, hair cycling in adult [22]

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Moreover, at the species level, Lactococcus lactis exhibited a significant moderate negative correlation with the clinical indices (Figure 5B, Supplementary Table 4)