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Anti Oxidant

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LTB4 is the predominant chemotactic mediator for neutrophils, leading to their recruitment into the lungs ( Purified human A1AT has been shown to inhibit neutrophil chemotaxis by reducing NE levels, thus attenuating the recruitment of neutrophils ( In a hamster model of fibrosis bleomycin induced, A1AT demonstrated to reduce neutrophil and lymphocyte migration already after 7 days, with a further decrease in cell counts (neutrophils, lymphocytes, and macrophages) after 30 days (71)