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α6 helix has a conserved tryptophan residue in GSTUs (Trp 161 in PtGSTU20) that is assumed to be one of the walls of the H-site (Figure 3) ( APO/GSH/GS-PAP , this tryptophan residue is buried (accessible surface area (ASA) of 4 Å 2 ), making the H-site quite deep (Supplementary Figure S6)