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In addition, in an in vitro model of ischemia stroke, administration of panax notoginseng saponins and NEC-1 could protect brain microvascular endothelial cells from oxygen glucose deprivation/reperfusion (OGD/R)-induced necroptosis by inhibiting the phosphorylation of RIP1, RIP3, and MLKL, suggesting that panax notoginseng saponins and NEC-1 effectively reduced the occurrence of necroptosis in ischemic stroke by inhibition of the RIP1/RIP3/MLK signaling pathway (Hu et al., 2022b)

This process not only aids in fat metabolism but also enhances endurance and performance