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Previous studies pointed out that antioxidant enzymes such as SOD, CAT, and GPx are crucial for protecting mitochondria from oxidative stress since the production of reactive species leads to mitochondrial damage, which is a key factor in the occurrence of neurodegenerative diseases ( According to previous research, caffeine was shown to increase Ca 2+ concentration in the vascular smooth muscle cells (VSMCs) through the cAMP pathway ( Conclusion In conclusion, our present study shows that L-theanine reverses the effects of caffeine on sleep disturbance, sleep disturbance-related brain chemistry alterations, and the caffeine’s effects on oxidative stress, where L-theanine seems to protect against neurodegenerative disorders

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(2003) 78:633S–9S