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One study found that vitamin B1 protected diabetic rats’ peripheral nerves against damage from high blood sugar, especially when the vitamin was in the form of ​​benfotiamine and given immediately after the diabetes was induced (rather than two months later)

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However, the heterogeneity test indicated moderate differences between studies reporting data on UPDRS Ⅲ (χ 2 =14.95, I 2 =60%, P=0.02), and therefore, the random-effects model was used (Fig

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