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The SILVA database was used to establish a taxonomy (release 138.2, Quast et al., 2013)

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First synthesized in the early 2000s, it replicates the first 29 amino acids of native GHRH with four strategic substitutions at positions 2, 8, 15, and 27 that resist cleavage by dipeptidyl peptidase-IV (DPP-IV)