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Disclosures: Paul Hayashi: Nothing to Disclose, Jasmine Amirzadegan: Nothing to Disclose, Edwige Chiogo Vouffo: Nothing to Disclose, Ling Lan: Nothing to Disclose, Eileen Navarro Almario: Nothing to Disclose, Mark Avigan: Nothing to Disclose 2646 THE PROTECTIVE ROLE OF SULFIREDOXIN-1 (SRXN1) IN ACETAMINOPHEN-INDUCED LIVER INJURY ★ mengyun ke 1 Jongwon Kim 1 Kate S Carroll 2 Wen Xie 1 , 1 University of Pittsburgh, 2 UF Scripps Biomedical Research Background: Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many Western countries