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GSH biosynthesis is transcriptionally controlled by NRF2, one critical oxidative stress-induced transcription factor being capable of promoting transcription of multiple antioxidant genes, including GCL(GCLC/GCLM), glutathione synthetase (GSS), and a subunit of the cystine/glutamate transporter xCT (SLC7A11) indispensable for GSH synthesis, as well as other redox enzymes utilizing GSH or NADPH to reduce the oxidized substrates, such as GPX4 [27, 28]
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The recommended IM dosage is 25 mg every 2 weeks, with titration up to 37.5 mg or 50 mg at intervals of at least 4 weeks