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Depletion of MST1/2 drives the formation of hepatocellular carcinoma and/or cholangiocarcinoma ( in vivo administration of Wnt/β-catenin (CHIR990221) and Hippo signaling activators (XMU-MP-1) will lead to tumorigenesis or affect tumor development in chronic liver failure recipients with hepatocellular carcinoma needs to be studied