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In terms of other ASC–GSH cycle members, H 2 O 2 from peroxisome that are MDAR4 functionally deficient diffuse to nearby oil body, causing oxidative damage to lipids and suppressing the triacylglycerol lipase activity of sugar-dependent 1 (SDP1) by carbonylation modification, resulting in blocked carbon source and seedling-lethal phenotype [56,61]

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Further, pulmonary endothelial cells from mice with mutated BMPR2 exhibit dysfunctional mitochondria and undergo a metabolic reprogramming that is shifted towards glutamine utilization [131]