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Among LOX alterations, those of LOX12/15 can lead to oxidative stress, resulting in free radical-dependent DNA damage and poly (ADP-ribose) polymerase-1 overactivation, neuronal degeneration and death (Czapski et al., 2013)

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Skipping the titration or escalating too quickly is one of the most common mistakes researchers make, and it almost always results in worse side effects without better results