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doi: 10.1038/nrneph.2013.22

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The researchers concluded from testing that when metabolically activated, "PAs produce DNA adducts, DNA cross-linking, DNA breaks, sister chromatid exchange, micronuclei, chromosomal aberrations, gene mutations, and chromosome mutations in vivo and in vitro ." [4] The most common mutation within the genes are G:C → T:A tranversions and tandem base substitution

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