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Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts

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has elegantly demonstrated that NRF2 is a key suppressor of ILC2 activation, our study provides the missing upstream link, identifying melatonin, a canonical circadian hormone, as a critical activator of the NRF2-Glutathione axis in ILC2s ( Initial analysis of our RNA-seq dataset comparing melatonin- and vehicle-treated ILC2s revealed broad suppression of pro-inflammatory gene expression following melatonin treatment, including canonical type 2 cytokines such as Il5 , Il13 , and Csf2