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During the trial, four participants (one in Sequence A and three in Sequence B) were excluded from the final analysis (Figure 1)

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Additionally, when combined with insulin, curcumin reduced the nuclear erythroid 2‐related compensatory factor 2 (Nrf2) pathway stimulation by lowering free radicals directly, and, in the early diabetes stage, it maintained Nrf2 pathway homeostasis better than insulin alone (Xie, Chen, et al., 2021)