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However, low concentrations of zinc are actually required by other interacting proteins of α-synuclein to prevent fibrillation ( 3 Role of zinc in modulation of α-synuclein fibrillation 3.1 Importance of zinc as a micronutrient in the body In nutrition, any chemical compound that is required in minute quantity (ranges between 1 and 100 mg/day in adults or constitutes 0%–1% of total body weight) is considered as a “trace element” (Stjernswärd et al., 1996)