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In a co-culture of colonic epithelial cells with peritoneal macrophages it restored the tight-junction proteins ZO-1 and occludin, and the authors traced the effect to the SIRT1/STAT3 axis: silencing STAT3 abolished the epithelial-healing effect (Mao et al., 2025)

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Screening cannot detect all cancers, but it substantially reduces the likelihood of undiagnosed tumors that might theoretically be affected by BPC-157