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Environment and TJ Regulation There have been new investigations into the effect of environmental factors such as drugs, stress, pollution, and dietary constituents on the TJ barrier

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ETHOS and IMPACT Trials and Mortality The ETHOS (Efficacy and Safety of Triple Therapy in Obstructive Lung Disease) and IMPACT (Informing the Pathway of COPD Treatment) trials suggested that triple therapy (a combination of inhaled corticosteroid (ICS), long-acting muscarinic antagonist (LAMA) and long-acting beta agonists (LABA) given in a single inhaler) may reduce mortality compared with dual bronchodilation