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Moreover, ccontinuous infusion of GLP-1 upregulated islet Pdx-1 gene expression and induced β-cell proliferation and neogenesis in rats [58]

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Thus, to address the limitations of free drugs and improve treatment effects, novel T7 peptide-modified nanoparticles (T7-CMCS-BAPE, CBT) was developed based on carboxymethyl chitosan (CMCS), which is capable of targeted binding to the transferrin receptor (TfR) expressed on lung cancer cells and precisely regulating drug-release according to the pH value and ROS level