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Efficacy was mixed -- weight loss observed in initial trials but not replicated in later studies that included intensive diet/exercise programs

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Interestingly, 94 of these miRNAs targeted genes within the IGF1R signaling pathway, among these IGF1R, IRS-1, AKT, Glycogen Synthase Kinase 3 (GSK3) α/β, MEK1, ERK 1/2, p38, p70, p90, Activating Transcription Factor (ATF)-2, and c-Jun N-terminal kinase (JNK)