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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Seco-Cervera M., González-Cabo P., Pallardó F.V., Romá-Mateo C., García-Giménez J.L

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This Fe 2+ fuels Fenton reactions, generating hydroxyl radicals that initiate acyl-CoA synthetaselong-chain family member 4 (ACSL4) / lysophosphatidylcholine acyltransferase 3(LPCAT3)-dependent lipid peroxidation: ACSL4 activates polyunsaturated fatty acids (PUFAs, e.g., arachidonic acid, AA/ adrenic acid, AdA), and then LPCAT3 incorporates them into membrane phospholipids (phosphatidylethanolamine-arachidonic acid/ adrenic acid, PE-AA/AdA), thus making them susceptible to oxidation by lipoxygenases (ALOXs