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Yes on both counts — semaglutide is a peptide (a GLP-1 receptor agonist) and it is FDA-approved, first approved as Ozempic for type 2 diabetes in 2017 and as Wegovy for chronic weight management in 2021

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In studies on cell lines, KPV was described as a compound that penetrates the cell and inhibits this translocation and related MAPK signaling (Luger and Brzoska 2007) – with an accompanying reduction of pro-inflammatory cytokines (IL-1, TNF-α, IL-6)