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Although numerous studies on magnetic NPs for biomedical applications, including cancer therapies, drug delivery, OA, and bone defect management, have been conducted and significant achievements have been made, there is still a great deal of work to be done [[178], [179], [180]]

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Importantly, metformin has been used to treat a group of LD patients and showed a beneficial effect by slowing down the progression of the disease [79]

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