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The term has emerged in media coverage and online communities as a label for retatrutide, a next‑generation injectable designed to activate three different hormone receptors involved in metabolism:​ GLP‑1 (glucagon‑like peptide‑1) GIP (glucose‑dependent insulinotropic polypeptide) Glucagon The logic behind the nickname is simple: Older drugs such as semaglutide (Ozempic, Wegovy) mainly target GLP‑1 (single agonist)

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