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Furthermore, the upregulation of the expression of ferroptosis-promoting factors, such as haem oxygenase-1 (HO-1), results in the degradation of haem and the release of more Fe²⁺, further promoting ferroptosis [19, 23]

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Biochemical abnormalities associated with ASD include impaired methylation and sulphation capacities along with low glutathione (GSH) redox capacity

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