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In HaCaT and primary keratinocyte cultures, KPV was not associated with cyclic AMP elevation but was associated with rapid intracellular calcium transients across a wide concentration range, alongside alpha-MSH and ACTH peptides [6]

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Table 1 gives an overview of MET/HGF-directed drugs that have been investigated in preclinical and/or clinical research and highlights those that have progressed to phase III trials