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Further, stress induced vascular permeability, an important event in inflammation is reduced in mast cell deficient mice (Kandere-Grzybowska et al., CRH activates mast cells to release various neuroinflammatory and neurotoxic mediators that leads to a breach of BBB and activates glial cells to release more inflammatory mediators, thereby contributing to the chronic neuroinflammation in the brain (Cao et al., 2013)