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TABLE 45-2 Dose-Limiting Extramedullary Toxicities of Single Alkylating Agents Cyclophosphamide and ifosfamide release a nephrotoxic and urotoxic metabolite, acrolein (see Figure 45-4), which causes a severe hemorrhagic cystitis in high-dose regimens

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Because mechanisms for paclitaxel-induced changes in neuronal sensitivity may differ between rodents and humans, research on human primary neurons and neuron-like cells induced from human pluripotent stem cells has surged in recent years