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Glutaredoxins are therefore key enzymes for redox catalysis and physiological processes such as DNA synthesis, signal transduction, and organ development 2,21,34,38,40,47,48

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78 Aberrant activation of oncogenic signaling pathways, such as WNT/β-catenin or PI3K-AKT, can suppress T-cell infiltration and contribute to a noninflamed tumor phenotype