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Additionally, blood–brain barrier disruption and infiltration of circulating macrophages have been observed in patients with childhood adrenoleukodystrophy (a severe form of X-ALD) ( Mfp2 gene, extensive microgliosis and increased mRNA levels of Tnf-α, Il-1b, Il-6, C1q , and Tlr2 were detected (Verheijden et al., 2013)