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Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial | Nature Medicine

In principle, this link might be conveyed by any output of mitochondrial activity, and, indeed, recent work suggests that exchange of calcium, reactive oxygen species (ROS), and potentially other metabolites between mitochondria and the ER likely influences metabolic disease progression (Tubbs et al., 2014

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Cerebrospinal fluid metabolomics: Detection of neuroinflammation in human central nervous system disease