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3.4 p38-mitogen-activated protein kinase signaling pathway Furthermore, there is compelling evidence indicating that HBOT influences the p38-mitogen-activated protein kinase (MAPK) signaling pathway, a serine/threonine protein kinase that plays a crucial role in cellular responses to various stress stimuli and a pivotal player in synaptic plasticity and the pathogenesis of neurodegenerative disorders (39, 40)